Dosimetry-based treatment for Graves’ disease

Radioiodine (131-I) treatment for Graves’ disease: Geant4 Monte Carlo simulation for patient personalized dose estimation

Background: Reliable estimation of radiation-absorbed dose is necessary to evaluate the benefits and the risks of radiopharmaceuticals used for diagnostic or therapeutic purposes in nuclear medicine. Materiel and Methods: This study included 47 patients treated with iodine-131 for Graves’ disease. A comparative study between Geant4 Monte Carlo simulation and MIRD formalism was carried out to ev...

Graves' disease development during sizofiran treatment.

It has been reported that various types of immunoactivators can induce Graves' disease. We describe here a case of Graves' disease during treatment with sizofiran, an immunoactivator. A 42-year-old woman who had previously been in an euthyroid state with Hashimoto's thyroiditis, experienced thyrotoxicosis during continuous administration of sizofiran as immunotherapy for endometrial carcinoma. ...

[Practical diagnosis and treatment of Graves' disease].

1.診断 (1)Basedow 病を疑う Basedow 病診断の第 1 歩はもちろん疑うことであ る.疑うきっかけは,体重減少,疲れやすい,動悸, 手指振戦,微熱,頻脈,低コレステロール血症など何 らかの代謝亢進を思わせる症状である.眼球突出は特 徴的な症状であるが,眼症状が軽いケースに気づくに はかなり経験が必要である.びまん性甲状腺腫もわか りにくいケースも多い. (2)診断のための検査 1)TSH と甲状腺ホルモン:甲状腺機能亢進症(甲状 腺中毒症)の診断は血液検査だけでよい.スクリーニ ングとして測定するのは TSH と遊離 T4 の 2 つでよ い.この 2 つが正常であれば甲状腺疾患は現在の症状 には関係していないと言い切れる.甲状腺疾患による 甲状腺機能亢進症であれば TSH は 0.01 μU ml 以下 に抑制され,遊離 T4 が上昇している.遊離 T4 が上昇 ...

Treatment of Graves’ Disease During Pregnancy

Graves’ disease is an autoimmune syndrome where thyroid stimulating antibodies bind to and activate the thyrotropin receptor on thyroid cells resulting in hyperthyroidism (Weetman, 2000; Jonklaas, 2011). Specifically, the production of thyroid-stimulating immunoglobulin (TSI) and thyroid-stimulating hormone-binding inhibitory immunoglobulin (TBII) act on the thyroid stimulating hormone receptor...

Radioiodine for Treatment of Graves’ Disease in Pediatric Population: An Ideal Treatment Radioiodine for Treatment of Graves’ Disease in Pediatric Population: An Ideal Treatment